PSYCHIATRY MCQs pdf free download. Q-1 Olanzapine is known to block D2 dopamine receptors. What other type of receptor does it mainly act on?
A. Alpha-adrenoceptors
B. Acetylcholine receptors
C. Serotonin receptors
D. D1 dopamine receptors
E. H1 histamine receptors
ANSWER:
Serotonin receptors
EXPLANATION:
Olanzapine, like other atypical antipsychotics, is known to block serotonin receptors (especially the 5-HT2 subtype) as well as D2 dopamine receptors
ATYPICAL ANTIPSYCHOTICS
Atypical antipsychotics should now be used first-line in patients with schizophrenia, according to 2005 NICE guidelines. The main advantage of the atypical agents is a significant reduction in extra-pyramidal side-effects.
Adverse effects of atypical antipsychotics
• weight gain
• clozapine is associated with agranulocytosis (see below)
The Medicines and Healthcare products Regulatory Agency has issued specific warnings when antipsychotics are used in elderly patients:
• increased risk of stroke
• increased risk of venous thromboembolism
Examples of atypical antipsychotics
• clozapine
• olanzapine
• risperidone
• quetiapine
• amisulpride
• aripiprazole
PSYCHIATRY MCQs pdf free download
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